Development and evaluation of matrix type transdermal patches of aspirin

Objective of the present study involves development and evaluation of matrix type transdermal patches for controlled delivery of aspirin as a model drug in order to avoid it,s frequent dosing , avoidance of adverse effects and improving the bioavailability of aspirin.Transdermal patches were prepare...

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Bibliographic Details
Published in:Oriental journal of chemistry 2008-01, Vol.24 (2), p.485
Main Authors: kumar, Kapil, sissodia, Neeraj, Rai, A K, Prajapati, S K
Format: Article
Language:English
Subjects:
Aspirin
Bioavailability
Buffers
Chitosan
Drug delivery systems
Patches (structures)
Physical properties
Polyethylene glycol
Polyvinylpyrrolidone
Propylene
Transdermal medication
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Summary:Objective of the present study involves development and evaluation of matrix type transdermal patches for controlled delivery of aspirin as a model drug in order to avoid it,s frequent dosing , avoidance of adverse effects and improving the bioavailability of aspirin.Transdermal patches were prepared by using different polymers i.e. Eudragit RS 100, chitosan ,polyethylene glycol 4000 and polyvinylpyrrolidone K30. Transdermal patches were evaluated in terms of physical properties and in-vitro release studies by using phosphate buffer of pH 5.0 and in-vitro skinpermeation studies was performed by using rat skin and phosphate buffer of pH 7.4 for 11 hrs. The effect of penetration enhancer (20 % propylene glycol) was estimated on the in-vitro skin permeation profile of the patches.
ISSN:0970-020X
2231-5039