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Do soy isoflavones cause endometrial hyperplasia?
For many years, hormone replacement therapy (HRT) was considered the gold standard for the symptomatic treatment of menopause. Clinical trials have found that HRT reduces the symptoms of hot flashes and sweating, while also decreasing vaginal dryness and urinary tract infections. HRT has also been s...
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| Published in: | Nutrition reviews 2005-11, Vol.63 (11), p.392-397 |
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| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4742-1bd2ffde058bc1b393602c9a6360a4ef97b75f7895c59f9af27f30bdf137580d3 |
| container_end_page | 397 |
| container_issue | 11 |
| container_start_page | 392 |
| container_title | Nutrition reviews |
| container_volume | 63 |
| creator | Mahady, G.B |
| description | For many years, hormone replacement therapy (HRT) was considered the gold standard for the symptomatic treatment of menopause. Clinical trials have found that HRT reduces the symptoms of hot flashes and sweating, while also decreasing vaginal dryness and urinary tract infections. HRT has also been shown to be protective against colon cancer (37%) and hip fractures (34%). However, recent findings from the Women's Health Initiative (WHI) have revealed that long-term HRT may actually lead to an increase in heart disease (29%), breast cancer (26%) and other adverse events, such as stroke (41%). Consequently, many women in the United States and abroad are actively looking for alternative treatments for menopause, including botanical dietary supplements. |
| doi_str_mv | 10.1111/j.1753-4887.2005.tb00376.x |
| format | article |
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Clinical trials have found that HRT reduces the symptoms of hot flashes and sweating, while also decreasing vaginal dryness and urinary tract infections. HRT has also been shown to be protective against colon cancer (37%) and hip fractures (34%). However, recent findings from the Women's Health Initiative (WHI) have revealed that long-term HRT may actually lead to an increase in heart disease (29%), breast cancer (26%) and other adverse events, such as stroke (41%). Consequently, many women in the United States and abroad are actively looking for alternative treatments for menopause, including botanical dietary supplements.</description><identifier>ISSN: 0029-6643</identifier><identifier>EISSN: 1753-4887</identifier><identifier>DOI: 10.1111/j.1753-4887.2005.tb00376.x</identifier><identifier>PMID: 16370224</identifier><identifier>CODEN: NUREA8</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>adverse effects ; animal models ; Animals ; Biological and medical sciences ; Cancer ; endometrial hyperplasia ; Endometrial Hyperplasia - chemically induced ; endometrium ; epidemiological studies ; estrogenic properties ; Feeding. Feeding behavior ; Female ; flavonoids ; Fundamental and applied biological sciences. Psychology ; Glycine max - adverse effects ; Hormone replacement therapy ; Hormones. Endocrine system ; human health ; Humans ; hyperplasia ; isoflavones ; Isoflavones - administration & dosage ; Isoflavones - adverse effects ; Macaca ; Medical sciences ; Medical treatment ; Menopause ; Menopause - physiology ; Mice ; Middle Aged ; Pharmacology. Drug treatments ; Plant Extracts - administration & dosage ; Plant Extracts - adverse effects ; Postmenopause - physiology ; soy ; soy intake ; Soy products ; soybean products ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Women</subject><ispartof>Nutrition reviews, 2005-11, Vol.63 (11), p.392-397</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright International Life Sciences Institute Nov 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4742-1bd2ffde058bc1b393602c9a6360a4ef97b75f7895c59f9af27f30bdf137580d3</citedby><cites>FETCH-LOGICAL-c4742-1bd2ffde058bc1b393602c9a6360a4ef97b75f7895c59f9af27f30bdf137580d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17293472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16370224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahady, G.B</creatorcontrib><title>Do soy isoflavones cause endometrial hyperplasia?</title><title>Nutrition reviews</title><addtitle>Nutr Rev</addtitle><description>For many years, hormone replacement therapy (HRT) was considered the gold standard for the symptomatic treatment of menopause. Clinical trials have found that HRT reduces the symptoms of hot flashes and sweating, while also decreasing vaginal dryness and urinary tract infections. HRT has also been shown to be protective against colon cancer (37%) and hip fractures (34%). However, recent findings from the Women's Health Initiative (WHI) have revealed that long-term HRT may actually lead to an increase in heart disease (29%), breast cancer (26%) and other adverse events, such as stroke (41%). Consequently, many women in the United States and abroad are actively looking for alternative treatments for menopause, including botanical dietary supplements.</description><subject>adverse effects</subject><subject>animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>endometrial hyperplasia</subject><subject>Endometrial Hyperplasia - chemically induced</subject><subject>endometrium</subject><subject>epidemiological studies</subject><subject>estrogenic properties</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>flavonoids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycine max - adverse effects</subject><subject>Hormone replacement therapy</subject><subject>Hormones. Endocrine system</subject><subject>human health</subject><subject>Humans</subject><subject>hyperplasia</subject><subject>isoflavones</subject><subject>Isoflavones - administration & dosage</subject><subject>Isoflavones - adverse effects</subject><subject>Macaca</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Menopause</subject><subject>Menopause - physiology</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - adverse effects</subject><subject>Postmenopause - physiology</subject><subject>soy</subject><subject>soy intake</subject><subject>Soy products</subject><subject>soybean products</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Women</subject><issn>0029-6643</issn><issn>1753-4887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqVkFFP2zAQxy00BB3bV2AREo8JZzux470gVBhMQt0Eq3g8OYk9UtK62O3Wfvs5SgTPu5d7uN_97_Qj5IxCRmNdLDIqC57mZSkzBlBkmwqAS5HtDsjkbfSBTACYSoXI-TH5GMICAChT_IgcU8ElMJZPCL12SXD7pA3OdvqPW5mQ1HobTGJWjVuajW91lzzv18avOx1affmJHFrdBfN57Cdk_u3m1_Quvf9x-316dZ_WucxZSquGWdsYKMqqphVXXACrlRax69xYJStZWFmqoi6UVdoyaTlUjaVcFiU0_IScDblr7163Jmxw4bZ-FU8io4xJEEJF6OsA1d6F4I3FtW-X2u-RAvaycIG9EeyNYC8LR1m4i8un44VttTTN--poJwLnI6BDrTvr9apuwzsno81csshdDtzftjP7_3gBZ_OHG676hHRIaMPG7N4StH9BIaMQfJrdYs6mVP68vsNZ5L8MvNUO9W8fv5o_MqAcKBQgFfB_9HKdvw</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Mahady, G.B</creator><general>Blackwell Publishing Ltd</general><general>International Life Sciences Institute</general><general>Oxford University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>200511</creationdate><title>Do soy isoflavones cause endometrial hyperplasia?</title><author>Mahady, G.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4742-1bd2ffde058bc1b393602c9a6360a4ef97b75f7895c59f9af27f30bdf137580d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>adverse effects</topic><topic>animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>endometrial hyperplasia</topic><topic>Endometrial Hyperplasia - chemically induced</topic><topic>endometrium</topic><topic>epidemiological studies</topic><topic>estrogenic properties</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>flavonoids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycine max - adverse effects</topic><topic>Hormone replacement therapy</topic><topic>Hormones. Endocrine system</topic><topic>human health</topic><topic>Humans</topic><topic>hyperplasia</topic><topic>isoflavones</topic><topic>Isoflavones - administration & dosage</topic><topic>Isoflavones - adverse effects</topic><topic>Macaca</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Menopause</topic><topic>Menopause - physiology</topic><topic>Mice</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - adverse effects</topic><topic>Postmenopause - physiology</topic><topic>soy</topic><topic>soy intake</topic><topic>Soy products</topic><topic>soybean products</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahady, G.B</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Agricultural Science Collection</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Nutrition reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahady, G.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do soy isoflavones cause endometrial hyperplasia?</atitle><jtitle>Nutrition reviews</jtitle><addtitle>Nutr Rev</addtitle><date>2005-11</date><risdate>2005</risdate><volume>63</volume><issue>11</issue><spage>392</spage><epage>397</epage><pages>392-397</pages><issn>0029-6643</issn><eissn>1753-4887</eissn><coden>NUREA8</coden><abstract>For many years, hormone replacement therapy (HRT) was considered the gold standard for the symptomatic treatment of menopause. Clinical trials have found that HRT reduces the symptoms of hot flashes and sweating, while also decreasing vaginal dryness and urinary tract infections. HRT has also been shown to be protective against colon cancer (37%) and hip fractures (34%). However, recent findings from the Women's Health Initiative (WHI) have revealed that long-term HRT may actually lead to an increase in heart disease (29%), breast cancer (26%) and other adverse events, such as stroke (41%). Consequently, many women in the United States and abroad are actively looking for alternative treatments for menopause, including botanical dietary supplements.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16370224</pmid><doi>10.1111/j.1753-4887.2005.tb00376.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrition reviews, 2005-11, Vol.63 (11), p.392-397 |
| issn | 0029-6643 1753-4887 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | adverse effects animal models Animals Biological and medical sciences Cancer endometrial hyperplasia Endometrial Hyperplasia - chemically induced endometrium epidemiological studies estrogenic properties Feeding. Feeding behavior Female flavonoids Fundamental and applied biological sciences. Psychology Glycine max - adverse effects Hormone replacement therapy Hormones. Endocrine system human health Humans hyperplasia isoflavones Isoflavones - administration & dosage Isoflavones - adverse effects Macaca Medical sciences Medical treatment Menopause Menopause - physiology Mice Middle Aged Pharmacology. Drug treatments Plant Extracts - administration & dosage Plant Extracts - adverse effects Postmenopause - physiology soy soy intake Soy products soybean products Vertebrates: anatomy and physiology, studies on body, several organs or systems Women |
| title | Do soy isoflavones cause endometrial hyperplasia? |
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