Protective role of jaboticaba Plinia peruviana peel extract in copper-induced cytotoxicity in Allium cepa

Jaboticaba Plinia peruviana (Poir.) Govaerts is a Brazilian berry that presents high levels of polyphenols, which may play a key role in preventing cytotoxic and genotoxic effects of harmful agents. Although copper is an essential micronutrient that plays an important role in organisms, high copper...

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Bibliographic Details
Published in:Environmental science and pollution research international 2018-12, Vol.25 (35), p.35322-35329
Main Authors: Franscescon, Francini, Mazon, Samara C., Bertoncello, Kanandra T., Boligon, Aline A., Sachett, Adrieli, Rambo, Cassiano L., Rosemberg, Denis B., Magro, Jacir Dal, Siebel, Anna M.
Format: Article
Language:English
Subjects:
Allium cepa
Anthocyanins
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Copper
Cytotoxicity
Deoxyribonucleic acid
Disturbances
DNA
DNA damage
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Fruits
Genotoxicity
Mitosis
Phenolic compounds
Phenols
Plant extracts
Polyphenols
Research Article
Toxicity
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Jaboticaba Plinia peruviana (Poir.) Govaerts is a Brazilian berry that presents high levels of polyphenols, which may play a key role in preventing cytotoxic and genotoxic effects of harmful agents. Although copper is an essential micronutrient that plays an important role in organisms, high copper concentrations may trigger toxicity to animals and plants. Here, we investigated whether Plinia peruviana hydroalcoholic extract prevents copper-induced cytotoxicity in Allium cepa root cells. Five different anthocyanins and phenolic compounds were identified in Plinia peruviana extract. Importantly, the exposure to 1.53 mg/L copper for 24 h impaired mitotic index, as well as increased mitosis disturbances and triggered DNA damage. Pre-incubation with Plinia peruviana extract (0.25 g/L and 0.75 g/L) for 3 h prevented copper-induced changes in the mitotic index and reduced the number of abnormal cells. In conclusion, we suggest that Plinia peruviana peel extract has protective effects against cellular and genetic disturbances induced by copper.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-018-3420-1