The Effect of Single Deuterium Substitutions for Protium in a DNA Molecule on the Occurrence of Open States

The data obtained by mathematical modeling of the occurrence of open states between nitrogenous bases in a D. melanogaster gene where a protium atom is replaced by deuterium are presented. It was shown that in the physiological range of deuterium concentrations substitution of deuterium for protium...

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Bibliographic Details
Published in:Biophysics (Oxford) 2018-07, Vol.63 (4), p.497-500
Main Authors: Dzhimak, S. S., Svidlov, A. A., Basov, A. A., Baryshev, M. G., Drobotenko, M. I.
Format: Article
Language:English
Subjects:
Bases (nucleic acids)
Biological and Medical Physics
Biophysics
Deoxyribonucleic acid
DNA
Environmental factors
Hydrogen bonding
Mathematical models
Molecular Biophysics
Physics
Physics and Astronomy
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Summary:The data obtained by mathematical modeling of the occurrence of open states between nitrogenous bases in a D. melanogaster gene where a protium atom is replaced by deuterium are presented. It was shown that in the physiological range of deuterium concentrations substitution of deuterium for protium increases the probability of hydrogen-bond disruption between complementary bases by 0.22–0.60%. This result suggests that deuterium can decelerate the transcriptional reading of genetic information. At the same time, under conditions that weaken the hydrogen bonds between the strands of a DNA molecule, replacement of protium with deuterium facilitates the formation of open states, increasing the probability of base modification induced by damaging environmental factors.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350918040061