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Euxanthone Attenuates Aβ1–42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and is characterized by the deposition of β-Amyloid (Aβ) plaques which contribute to its pathology. The present study was aimed at exploring the protective effects of euxanthone against Aβ-induced neurotoxicity both in vivo and i...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2018-12, Vol.66 (4), p.512-523
Main Authors: Yuan, Haicheng, Jiang, Chuanwu, Zhao, Jingde, Zhao, Yunsheng, Zhang, Yongbin, Xu, Yanqi, Gao, Xiaoning, Guo, Lingfei, Liu, Yongji, Liu, Kai, Xu, Bo, Sun, Gang
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Language:English
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Summary:Alzheimer’s disease (AD) is the most common neurodegenerative disorder and is characterized by the deposition of β-Amyloid (Aβ) plaques which contribute to its pathology. The present study was aimed at exploring the protective effects of euxanthone against Aβ-induced neurotoxicity both in vivo and in vitro. We found that euxanthone significantly attenuated Aβ 1-42 -induced memory and spatial learning dysfunction and also significantly reversed Aβ 1-42 -induced neuronal apoptosis and autophagy in the hippocampal region. Euxanthone also protected the neuroblastic PC12 cells against Aβ 1-42 -induced oxidative stress and apoptosis by inducing autophagy. In conclusion, euxanthone exerts its neuroprotective effect against Aβ 1-42 by inducing autophagy, indicating its potential therapeutic role in AD.
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-018-1175-2