Rheumatoid Arthritis: Hyaluronic Acid and Cartilage Oligomeric Matrix Protein as Predictors of the Disease Progression

The aim of the present study was to measure the serum concentrations of specific cartilage and bone biomarkers reflecting tissue turnover, particularly hyaluronic acid and cartilage oligomeric matrix protein, to investigate disease activity. The study included 60 patients of rheumatoid arthritis wit...

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Bibliographic Details
Published in:Biomedical & pharmacology journal 2016, Vol.9 (1), p.15-23
Main Authors: AL-DALAEN, SAID, AL-QTAITAT, AIMAN, AL-RAWASHDEH, MOHAMMAD, ALZYOUD, JIHAD, AL-MAATHADI, AIMAN
Format: Article
Language:English
Subjects:
Biomarkers
Bone matrix
Bone surgery
Bone turnover
Cartilage
Cartilage oligomeric matrix protein
Enzymes
Erythrocyte sedimentation rate
Extracellular matrix
Family medical history
Hyaluronic acid
Laboratories
Matrix protein
Orthopedics
Patients
Proteins
Psoriasis
Rheumatoid arthritis
Rheumatology
Serum levels
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Summary:The aim of the present study was to measure the serum concentrations of specific cartilage and bone biomarkers reflecting tissue turnover, particularly hyaluronic acid and cartilage oligomeric matrix protein, to investigate disease activity. The study included 60 patients of rheumatoid arthritis with age range 43-66 years; thirty patients were rapid erosive patients and thirty were slow erosive, compared to twenty matched normal population with age range 46-63 years. All individuals enrolled in the study were subjected to full history taking, clinical examination and necessary laboratory investigation. The study showed significantly (P
ISSN:0974-6242
2456-2610
DOI:10.13005/bpj/903