Comparison of the Effects of Intrathecal Midazolam and Tramadol with the Conventional Method of Postoperative Pain and Shivering Control after Elective Cesarean Section

Pain is a complex medical issue. Lack of postoperative pain relief adversely affects the physiological, metabolic and mental conditions of patients. Duration of analgesia could increase by using additional supplements. This study aimed to compare the effects of intrathecal midazolam and tramadol wit...

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Bibliographic Details
Published in:Biomedical & pharmacology journal 2016, Vol.9 (3), p.995-1003
Main Authors: PAZUKI, SHIRIN, KAMALI, ALIREZA, SHAHROKHI, NASIM, JAMILIAN, MEHRI
Format: Article
Language:English
Subjects:
Analgesia
Analgesics
Anesthesia
Cesarean section
Clinical trials
Drug dosages
Intensive care
Lidocaine
Medical personnel
Midazolam
Pain
Pain perception
Patient satisfaction
Researchers
Surgery
Tramadol
Variance analysis
Womens health
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Summary:Pain is a complex medical issue. Lack of postoperative pain relief adversely affects the physiological, metabolic and mental conditions of patients. Duration of analgesia could increase by using additional supplements. This study aimed to compare the effects of intrathecal midazolam and tramadol with the conventional method of postoperative pain and shivering control after elective cesarean section. This double-blind randomized clinical trial was conducted on 210 women aged 20 - 35 years with ASA class I and II who were candidates for elective cesarean section. Subjects were randomly divided into three groups of midazolam, tramadol and control to receive hyperbaric lidocaine and midazolam (2 mg), tramadol (25 mg), and normal saline (5 cc), respectively. Using the visual analogue scale (VAS), postoperative pain score and analgesia duration were assessed and compared between the groups. Moreover, scores of shivering during and after the surgery were compared between the groups. According to the results of Kruskal-Wallis, mean score of postoperative analgesia duration was significantly higher in the tramadol group compared to the other groups, while it was higher in the midazolam group compared to control subjects (P
ISSN:0974-6242
2456-2610
DOI:10.13005/bpj/1039