Mangifera Indica Leaves Extract Effect on Liver Function in Experimental Animal Studies

This experimental study was undertaken to see the hepatoprotective activity of ethanol extract of Mangifera-indica dried leaves against CCl 4 induced acute liver damage on albino rats. CCl 4 (1ml/kg) significantly elevated the serum levels of biochemical markers like SGPT, SGOT, ALP, Total bilirubin...

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Bibliographic Details
Published in:Biomedical & pharmacology journal 2016, Vol.9 (3), p.1009-1012
Main Authors: KUMAR NADELLA, SIVA, RAVEENDRA KUMAR, N .
Format: Article
Language:English
Subjects:
Albinism
Animals
Antioxidants
Ayurvedic medicine
Bilirubin
Biochemical markers
Drugs
Enzymes
Ethanol
Hazardous materials
Herbal medicine
Leaves
Liver
Liver diseases
Mangifera
Pesticides
Prevention
Serum levels
Solvents
Toxicity
Variance analysis
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Summary:This experimental study was undertaken to see the hepatoprotective activity of ethanol extract of Mangifera-indica dried leaves against CCl 4 induced acute liver damage on albino rats. CCl 4 (1ml/kg) significantly elevated the serum levels of biochemical markers like SGPT, SGOT, ALP, Total bilirubin, Protein and depleted antioxidant enzymes GSH upon administration of CCl 4 (1ml/kg) to albino rats. After treatment with MI leaf Extract (300mg/kg), MI leaf Extract (600mg/kg) for two weeks there is significantly reduced the elevated levels of biochemical markers mentioned above. These results suggest that this MI leaf Extract may have the potential therapeutic value in the treatment of CCl 4 induced hepatic damage and some liver diseases. Hepatoprotective activity of this extract may be attributed to the anti-oxidant principles in it.
ISSN:0974-6242
2456-2610
DOI:10.13005/bpj/1041