Study of Oxidative Stress in Essential Hypertension

Essential hypertension is associated with an elevation of reactive oxygen species (ROS) which reacts with membrane lipids to form lipid hydroperoxides that decomposes to form Malondialdehyde (MDA) an indicator of oxidative stress. Endogenous antioxidant enzyme, Superoxide dismutase (SOD) counteracts...

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Bibliographic Details
Published in:Biomedical & pharmacology journal 2015-06, Vol.8 (1), p.463-466
Main Authors: AGARWAL, B.K., SAXENA, TRIPTI, NAZ, SABIHA
Format: Article
Language:English
Subjects:
Antihypertensives
Antioxidants
Arteriosclerosis
Blood pressure
Body mass index
Cardiovascular disease
Colorimetry
Coronary artery
Diabetes mellitus
Heart diseases
Hypertension
Lipid peroxidation
Lipids
Malondialdehyde
Nitric oxide
Oxidative stress
Proteins
Reactive oxygen species
Statistical analysis
Superoxide dismutase
Tumor necrosis factor-TNF
Vegetable oils
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Summary:Essential hypertension is associated with an elevation of reactive oxygen species (ROS) which reacts with membrane lipids to form lipid hydroperoxides that decomposes to form Malondialdehyde (MDA) an indicator of oxidative stress. Endogenous antioxidant enzyme, Superoxide dismutase (SOD) counteracts oxidative stress. This study aims at understanding the role of oxidative stress in essential hypertension. The study comprised of 50 confirmed cases of hypertension and 50 age and sex matched controls .Inclusion criteria includes patients with blood pressure ≥ 140/90 mm of Hg, while patients with secondary hypertension, stroke, CAD,MI and diabetes mellitus are excluded. Serum SOD estimated spectrophotometrically by Mishra H.P. and Fridovich I,1972 method and Plasma MDA by colorimetric method of Satoch K.et al. SOD activity was statistically significantly (p
ISSN:0974-6242
2456-2610
DOI:10.13005/bpj/635