3-HMG-Coa Reductase Inhibitor Modulates Parasitological Response in Malaria Patients Treated with Amodiaquine

The occurrence of parasitological resistance to amodiaquine has been reported globally. The 3-HMG CoA reductase inhibitors, otherwise known as statins have been shown to inhibit the growth of malaria parasite.This study was aimed at evaluating the effects of simvastatin in modulating parasitological...

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Bibliographic Details
Published in:Biomedical & pharmacology journal 2014-12, Vol.7 (2), p.439-444
Main Authors: Nwobodo, Ndubuisi N., Okonkwo, Paul O.
Format: Article
Language:English
Subjects:
Amodiaquine
Blood
Chemotherapy
Data processing
Dihydrofolate reductase
Drug dosages
Erythrocytes
Health facilities
HMG-CoA reductase inhibitors
Hydroxymethylglutaryl-CoA reductase
Infections
Malaria
Mutation
Parasites
Patients
Simvastatin
Statins
Statistical analysis
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Summary:The occurrence of parasitological resistance to amodiaquine has been reported globally. The 3-HMG CoA reductase inhibitors, otherwise known as statins have been shown to inhibit the growth of malaria parasite.This study was aimed at evaluating the effects of simvastatin in modulating parasitological response to amodiaquine in the chemotherapy of malaria. Subjects with frank malaria (n=60) diagnosed by thick blood film and and confirmed using immunological tests were nominated for the study. Informed written content was obtained and subjects randomized into amodiaquine plus simvastatin (test) and amodiaquine alone (control) groups. The ethical clearance certificate was obtained from the University of Nigeria Teaching Hospital Research Ethics Committee (NHREC/05/01/2008B). The assessment of parasitological response was done in line with WHO criteria and patients followed up on days D0, D3, D7, D14 and D28 post-treatment. The GraphPad Prism 4.0 was employed in the analysis of data which was presented as tables and graphs. Revealed a statistically significant difference in parasitological response (p
ISSN:0974-6242
2456-2610
DOI:10.13005/bpj/509