Protective Role of Whole and Anthocyanin-free Aqueous Extracts of Hibiscus Sabdariffa L. on Cadmium-induced Prostate, Testicular and Nephro Toxicity Markers in Male Wistar Rats

Cadmium is one of the extremely toxic metals commonly found in industrial work places with very low permissible exposure limit (PEL). Exposure to cadmium has been associated with organ toxicity which can culminate in cancer of the prostate and testis. Cadmium elicits its toxicity via free radical ge...

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Bibliographic Details
Published in:Biomedical & pharmacology journal 2008-01, Vol.1 (2), p.281
Main Authors: Fadairo, E A, Birma, G J, Obi, F O, Opajobi, A O, Onyesom, I
Format: Article
Language:English
Subjects:
Acid phosphatase
Antioxidants
Body weight
Cadmium
Cancer
Catalase
Heavy metals
Lipid peroxidation
Lipids
Malondialdehyde
Phosphatase
Pigments
Plant extracts
Prostate
Prostate cancer
Rodents
Superoxide dismutase
Testes
Toxicity
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Summary:Cadmium is one of the extremely toxic metals commonly found in industrial work places with very low permissible exposure limit (PEL). Exposure to cadmium has been associated with organ toxicity which can culminate in cancer of the prostate and testis. Cadmium elicits its toxicity via free radical generation and associated oxidative damage. Some plant extracts are known to contain anti-oxidant pigments. The influence of whole and anthocyanin free aqueous extracts of Hibiscus sabdariffa , L. on cadmium- induced prostate, testicular and nephro toxicity in male wistar rats was studied using a combination of organ: body weight ratio, total and prostatic acid phosphatase activity, organ superoxide dismutase activity, catalase activity, and malondialdehyde (MDA) levels. Cadmium treated rats had significantly ( P
ISSN:0974-6242
2456-2610