Chrono pharmaceutical drug delivery system

In the body under physiological conditions, many vital functions are regulated by transient release of bioactive substances at a specific time and site. Thus, to mimic the function of living systems and in view of emerging chronotherapeutic approaches, pulsatile delivery, which is meant to release a...

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Bibliographic Details
Published in:Biomedical & pharmacology journal 2009-12, Vol.2 (2), p.333
Main Authors: Ravichandiran, V, Suba, V, Umadevi, S K, Jayavasavi, G, Kausalya, J, Saraswathy, T
Format: Article
Language:English
Subjects:
Acids
Angina pectoris
Asthma
Bioavailability
Cellulose acetate
Circadian rhythm
Drug delivery
Drug delivery systems
Drug dosages
Gastric emptying
Lag phase
Membrane permeability
Metabolism
Pharmaceuticals
Polymers
Polyvinyl alcohol
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Summary:In the body under physiological conditions, many vital functions are regulated by transient release of bioactive substances at a specific time and site. Thus, to mimic the function of living systems and in view of emerging chronotherapeutic approaches, pulsatile delivery, which is meant to release a drug following programmed lag phase, has attracted increasing interest in recent years. In pursuit of pulsatile release, various design strategies have been proposed, broadly categorized into single-unit and multiple-unit systems. However, in recent pharmaceutical applications involving pulsatile delivery, multiparticulate dosage forms are gaining much favor over single-unit dosage forms because of their potential benefits like predictable gastric emptying, no risk of dose dumping, flexible release patterns and increased bioavailability with less inter- and intra-subject variability. Based on these premises, the aim of the present review is to survey the main multiparticulate pulsatile delivery systems, for which the swelling and rupturing; dissolution or erosion; and changed permeability of the coating membrane are primarily involved in the control of release. The development of low density floating multiparticulate pulsed-release dosage forms possessing gastric retention capabilities has also been addressed with increasing focus on the upcoming multiparticulate-pulsatile technologies being exploited on an industrial scale.
ISSN:0974-6242
2456-2610