All-optical photoacoustic microscopy based on plasmonic detection of broadband ultrasound

We report on an implementation of all-optical photoacoustic microscopy (PAM), which capitalizes on the effect of surface plasmon resonance (SPR) for optical detection of ultrasound. The SPR sensor in our all-optical PAM shows, experimentally, a linear response to the acoustic pressure from 5.2 kPa t...

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Bibliographic Details
Published in:Applied physics letters 2015-10, Vol.107 (15)
Main Authors: Wang, Tianxiong, Cao, Rui, Ning, Bo, Dixon, Adam J., Hossack, John A., Klibanov, Alexander L., Zhou, Qifa, Wang, Anbo, Hu, Song
Format: Article
Language:English
Subjects:
Acoustic noise
Anisotropy
Applied physics
Broadband
Frequency response
Image resolution
Microscopy
Noise levels
Noise sensitivity
Photoacoustic microscopy
Spatial resolution
Ultrasonic imaging
Ultrasonic testing
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Summary:We report on an implementation of all-optical photoacoustic microscopy (PAM), which capitalizes on the effect of surface plasmon resonance (SPR) for optical detection of ultrasound. The SPR sensor in our all-optical PAM shows, experimentally, a linear response to the acoustic pressure from 5.2 kPa to 2.1 MPa, an ultra-flat frequency response (±0.7 dB) from 680 kHz to 126 MHz, and a noise-equivalent pressure sensitivity of 3.3 kPa. With the broadband ultrasonic detection, our SPR-PAM has achieved high spatial resolution with relatively low anisotropy (i.e., 2.0 μm laterally and 8.4 μm axially). Three-dimensional high-resolution imaging of a single melanoma cell is demonstrated.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.4933333