Effects of diphenyl diselenide diet on a model of mercury poisoning

This work investigated the preventive effect of diphenyl diselenide [(PhSe) 2 ] against the toxic effects of mercury in silver catfish ( Rhamdia quelen ). The animals were treated during 30 consecutive days with a (PhSe) 2 supplemented feed (3.0 mg kg −1 ) or commercial feed. During the last 5 days...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology reports 2018-12, Vol.45 (6), p.2631-2639
Main Authors: da Luz Fiuza, Tiago, Leitemperger, Jossiele, Severo, Eduardo Stringini, Marins, Aline Teixeira, do Amaral, Aline Blank, Pereira, Maria Ester, Loro, Vania Lucia
Format: Article
Language:English
Subjects:
Ammonia
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Blood
Creatinine
Feed additives
Histology
Kidneys
Life Sciences
Liver
Mercuric chloride
Mercury
Morphology
Original Article
Protein thiols
Spinal cord
Thiols
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This work investigated the preventive effect of diphenyl diselenide [(PhSe) 2 ] against the toxic effects of mercury in silver catfish ( Rhamdia quelen ). The animals were treated during 30 consecutive days with a (PhSe) 2 supplemented feed (3.0 mg kg −1 ) or commercial feed. During the last 5 days the animals received a daily intraperitoneal dose of HgCl 2 (1.7 mg kg −1 ) or Saline (0.9%). Twenty-four hours after the last HgCl 2 injection, the animals were euthanized by spinal cord section to biological material obtainment. Hepatic (AST and ALT) and renal (ammonia and creatinine) toxicity biomarkers, δ-ALA-D activity, TBARS, total and non-protein thiols levels and hepatic, renal and blood mercury (Hg) and zinc (Zn) content were evaluated. Considering renal parameters, HgCl 2 exposition increased serum creatinine levels and decreased δ-ALA-D activity, total and non-protein thiols and TBARS levels. HgCl 2 exposure also decreased blood δ-ALA-D activity. With exception of blood δ-ALA-D activity and total thiols levels, (PhSe) 2 supplementation partially prevented mercury induced alterations. Animals exposed to HgCl 2 presented an increase in liver and kidney Hg content and a decrease in liver and blood Zn content. The alteration in blood Zn content was partially prevented with (PhSe) 2 supplementation. With the exception of mercury and zinc content, no effects of HgCl 2 exposure on hepatic tissue were observed. These results show that (PhSe) 2 supplementation can represent a promising alternative to prevent the toxic effects presented by Hg exposure.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-018-4433-z