In vitro effects of radioactive properties of 99mTc and 99mTc-MDP on human glucose 6-phosphate dehydrogenase activity

The inhibitory effects of Na99mTcO4 (Sodium pertechnetate) and Na99mTcO4-metilendifosfonat (MDP) on human erythrocyte glucose 6-phosphate dehydrogenase (hG6PD) activity were investigated. For this purpose, hG6PD was initially purified 557-fold at a yield of 51.43% using 2’,5’-adenosine diphosphate (...

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Bibliographic Details
Main Authors: Sahin, Ali, Senturk, Murat
Format: Conference Proceeding
Language:English
Subjects:
Adenosine diphosphate
Dehydrogenases
Enzymes
Erythrocytes
Glucose 6 phosphate dehydrogenase
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Summary:The inhibitory effects of Na99mTcO4 (Sodium pertechnetate) and Na99mTcO4-metilendifosfonat (MDP) on human erythrocyte glucose 6-phosphate dehydrogenase (hG6PD) activity were investigated. For this purpose, hG6PD was initially purified 557-fold at a yield of 51.43% using 2’,5’-adenosine diphosphate (ADP) sepharose 4B affinity gel chromatography. The in vitro effects of these compounds on hG6PD enzyme were studied. It was detected in in vitro studies that the hG6PD enzyme is inhibited due to Na99mTcO4 and Na99mTcO4-metilendifosfonat (MDP).
ISSN:0094-243X
1551-7616
DOI:10.1063/1.4981759