Encapsulation of chlorine-containing carbamates in polypeptide nanoparticles prepared by enzymatic hydrolysis of casein

Encapsulation of biologically active β-oxalylamino substituted O -ethylcarbamate in micelles of non-hydrolyzed and hydrolyzed casein is performed. The AFM studies show that the controlled hydrolysis of casein by trypsine allows preparation of monodisperse nanoparticles with a mean size of 22 nm and...

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Bibliographic Details
Published in:Russian chemical bulletin 2018-08, Vol.67 (8), p.1508-1512
Main Authors: Vorob’ev, M. M., Khomenkov, V. S., Sinitsyna, O. V., Levinskaya, O. A., Kitaeva, D. Kh, Kalistratova, A. V., Oshchepkov, M. S., Kovalenko, L. V., Kochetkov, K. A.
Format: Article
Language:English
Subjects:
Carbamates (tradename)
Casein
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chlorine
Coulometers
Encapsulation
Hydrolysis
Inorganic Chemistry
Micelles
Nanoparticles
Organic Chemistry
Solubilization
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Summary:Encapsulation of biologically active β-oxalylamino substituted O -ethylcarbamate in micelles of non-hydrolyzed and hydrolyzed casein is performed. The AFM studies show that the controlled hydrolysis of casein by trypsine allows preparation of monodisperse nanoparticles with a mean size of 22 nm and with a dispersion of 5 nm. The high-precision coulometric method for the chlorine detection shows that, as compared with initial casein micelles, the formed nanoparticles involve appreciable amounts of chlorine-containing alkylcarbamate. Micellar solubilization allows the preparation of the colloidal form of alkylcarbamate form, which is suitable for its practical application.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-018-2248-7