LINC 01287 regulates tumorigenesis and invasion via miR‐298/ MYB in hepatocellular carcinoma

Recently, it was reported that long non‐coding RNA s (lnc RNA s) participated in promoting hepatocellular carcinoma ( HCC ) initiation and progression. Herein, we reported that the expression level of LINC 01287 was elevated in HCC cell lines and tissues. LINC 01287 down‐regulation inhibited HCC cel...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2018-11, Vol.22 (11), p.5477-5485
Main Authors: Mo, Yichao, He, Longguang, Lai, Zeru, Wan, Zhiheng, Chen, Qinshou, Pan, Sibo, Li, Liangfu, Li, Dasheng, Huang, Junwei, Xue, Fan, Che, Siyao
Format: Article
Language:English
Subjects:
Cell lines
Hepatocellular carcinoma
Liver cancer
Tumorigenesis
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Summary:Recently, it was reported that long non‐coding RNA s (lnc RNA s) participated in promoting hepatocellular carcinoma ( HCC ) initiation and progression. Herein, we reported that the expression level of LINC 01287 was elevated in HCC cell lines and tissues. LINC 01287 down‐regulation inhibited HCC cells growth and invasion both in vitro and in vivo. LINC 01287 exerted as a ce RNA and negatively regulated miR‐298 expression. MYB was identified as a downstream target of miR‐298. The miR‐298/ MYB axis mediated LINC 01287's effect on HCC . To the best of our knowledge, our findings provided the first evidence that LINC 01287 functioned as an oncogene in HCC . LINC 01287 may be a candidate prognostic biomarker and a target for new therapies in HCC patients.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.13818