Graphene oxide-Fe3O4 nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging

The potential of graphene oxide–Fe3O4 nanoparticle (GO-Fe3O4) composite as an image contrast enhancing material in magnetic resonance imaging has been investigated. Proton relaxivity values were obtained in three different homogeneous dispersions of GO-Fe3O4 composites synthesized by precipitating F...

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Bibliographic Details
Published in:Journal of applied physics 2015-04, Vol.117 (15)
Main Authors: Venkatesha, N., Poojar, Pavan, Qurishi, Yasrib, Geethanath, Sairam, Srivastava, Chandan
Format: Article
Language:English
Subjects:
Applied physics
Biocompatibility
Chemical synthesis
Composite materials
Graphene
Image contrast
Image enhancement
Iron oxides
Magnetic properties
Magnetic resonance imaging
Nanoparticles
NMR
Nuclear magnetic resonance
Protons
Reduction
Sheets
Structural analysis
Toxicity
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Summary:The potential of graphene oxide–Fe3O4 nanoparticle (GO-Fe3O4) composite as an image contrast enhancing material in magnetic resonance imaging has been investigated. Proton relaxivity values were obtained in three different homogeneous dispersions of GO-Fe3O4 composites synthesized by precipitating Fe3O4 nanoparticles in three different reaction mixtures containing 0.01 g, 0.1 g, and 0.2 g of graphene oxide. A noticeable difference in proton relaxivity values was observed between the three cases. A comprehensive structural and magnetic characterization revealed discrete differences in the extent of reduction of the graphene oxide and spacing between the graphene oxide sheets in the three composites. The GO-Fe3O4 composite framework that contained graphene oxide with least extent of reduction of the carboxyl groups and largest spacing between the graphene oxide sheets provided the optimum structure for yielding a very high transverse proton relaxivity value. It was found that the GO-Fe3O4 composites possessed good biocompatibility with normal cell lines, whereas they exhibited considerable toxicity towards breast cancer cells.
ISSN:0021-8979
1089-7550
DOI:10.1063/1.4918605