Natural Products Extraction of the Future—Sustainable Manufacturing Solutions for Societal Needs

The production of plant-based extracts is significantly influenced by traditional techniques and the natural variability of feedstock. For that reason, the discussion of innovative approaches to improve the manufacturing of established products and the development of new products within the regulato...

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Bibliographic Details
Published in:Processes 2018-10, Vol.6 (10), p.177
Main Authors: Uhlenbrock, Lukas, Sixt, Maximilian, Tegtmeier, Martin, Schulz, Hartwig, Hagels, Hansjörg, Ditz, Reinhard, Strube, Jochen
Format: Article
Language:English
Subjects:
Antibiotics
Automatic control
Business models
Control methods
Cosmetics
Costs
Drugs
FDA approval
Federal regulation
Food
Herbal medicine
Innovations
Laboratory equipment
Manufacturers
Manufacturing
Natural products
Nutrition
Organic chemistry
Pharmaceutical industry
Plant extracts
Quality control
Quality standards
R&D
Research & development
Technology assessment
Trends
Value chain
Working groups
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Summary:The production of plant-based extracts is significantly influenced by traditional techniques and the natural variability of feedstock. For that reason, the discussion of innovative approaches to improve the manufacturing of established products and the development of new products within the regulatory framework is essential to adapt to shifting quality standards. This perspective of members of the DECHEMA/ProcessNet working group on plant-based extracts outlines extraction business models and the regulatory framework regarding the extraction of traditional herbal medicines as complex extracts. Consequently, modern approaches to innovative process design methods like QbD (Quality by Design) and quality control in the form of PAT (Process Analytical Technology) are necessary. Further, the benefit of standardized laboratory equipment combined with physico-chemical predictive process modelling and innovative modular, flexible batch or continuous manufacturing technologies which are fully automated by advanced process control methods are described. A significant reduction of the cost of goods, i.e., by a factor of 4–10, and decreased investments of about 1–5 mil. € show the potential for new products which are in line with market requirements.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr6100177