Investigation of antimicrobial properties and in‐vitro bioactivity of Ce3+‐Sr2+dual‐substituted nano hydroxyapatites

Dual doped calcium apatite has been widely focused as it enhances the osteoconductive property for the possible applications in orthopedic and dental implants. In this work, we investigate the antimicrobial and bioactive properties of cerium/strontium (Ce3+/Sr2+) co‐substituted hydroxyapatite (HA) n...

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Bibliographic Details
Published in:Journal of the American Ceramic Society 2019-01, Vol.102 (1), p.144-157
Main Authors: Sundarabharathi, Lakshmanaperumal, Chinnaswamy, Mahendran, Ponnamma, Deepalekshmi, Parangusan, Hemalatha, Al‐Maadeed, Mariam Al Ali
Format: Article
Language:English
Subjects:
Apatite
bioactivity
Biocompatibility
Biological activity
Biological properties
Biomedical materials
Cerium
Comparative studies
Dental implants
Dental materials
Functional groups
Hydroxyapatite
live cell imaging
Morphology
Nanoparticles
Photoluminescence
Sol-gel processes
Sol‐gel
Substitutes
Surgical implants
Thermal decomposition
Thermal stability
Transplants & implants
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Summary:Dual doped calcium apatite has been widely focused as it enhances the osteoconductive property for the possible applications in orthopedic and dental implants. In this work, we investigate the antimicrobial and bioactive properties of cerium/strontium (Ce3+/Sr2+) co‐substituted hydroxyapatite (HA) nanoparticles synthesized by sol‐gel assisted precipitation method. The structure, morphology, functional groups, photoluminescence, and thermal stability of the developed systems are examined. The comparative studies performed among the pure HA, Sr2+, and Ce3+‐substituted HA nanoparticles illustrate higher antibacterial activity with lowered apatite‐forming ability and biocompatibility for the Ce3+‐substituted HA. However, the Ce3+/Sr2+co‐substituted HA exhibits better biocompatibility, apatite‐forming ability, and good antimicrobial properties. Sr2+ ion inclusion leads to better biological properties and compromise the cytotoxic nature of the Ce3+‐HA. In addition, the Ce3+/Sr2+‐HA nanoparticles prevent thermal decomposition up to 700°C, pointing also toward the possibility of this co‐substituted HA in bone implant applications. Three defining dynamics of authentic participatory research
ISSN:0002-7820
1551-2916
DOI:10.1111/jace.15866