Magnetic field calculations for iron oxide nanoparticles for MRI

• Main Authors: Hernandez, Ricardo, Miguel Mendez Rojas, Pilar Dies Suarez, Silvia Hidalgo Tobón
• Format: Conference Proceeding
• Language: English
• Subjects: Capillary tubes; Contrast media; Electric contacts; Image acquisition; Iron oxides; Linear polarization; Magnetic fields; Magnetic permeability; Magnetic resonance imaging; Magnetism; Mathematical analysis; Nanoparticles; Plane waves; Propagation
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/1.4901378

The susceptibility effects of superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with triethylenglycol (TREG) and Polyethylen Glycol (PEG) has been studied, those nanoparticles have the necessary properties to be used in the clinic as contrast media in imaging by MRI[1–3]. We are considering the behavior of the magnetic field as plane wave to explain the electrical and magnetic field produced by SPIONs. Images were acquired on a 1.5T imager Philips, using mFFE Sequence. Three glass capillary tubes with a) TREG (10nm) concentration of 300 μg/ml, and PEGCOOH 6000(10nm) with 300 μg/ml, and 2% agarosa. Magnetic field simulations were calculated in Matlab. The plane wave that comes in contact with a sphere of radius a, an propagation constant k1, and it is in an homogeneous space k2. We consider that the electric field is linearly polarized on x-direction, with a propagation on z-positive-axis. The secondary induced field can be explained from the interior of the sphere and valid exterior points. The referred waves are transmitted and reflected, this is valid only when the wavelength is smaller than the radius of the sphere. The obtained vibrational mode is an answer of the electrical oscillation and this is projection of the disturbed magnetic field. TREG-SPIONs produce more serious susceptibility artefacts compared to PEG-SPIONs. This study is promissory due to the concordance of the results of the simulations and the inhomogeneities showed in the MR images.