Randomized crossover comparison of DDDR versus VDD pacing after atrioventricular junction ablation for prevention of atrial fibrillation

Background —Some clinical data suggest that atrial-based pacing prevents paroxysmal atrial fibrillation (AF). This study tested the hypothesis that DDDR pacing compared with VDD pacing prevents AF after atrioventricular (AV) junction ablation. Methods and Results —Patients were randomized to DDDR pa...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2000-08, Vol.102 (7), p.736-741
Main Authors: GILLIS, A. M, CONNOLLY, S. J, GARDNER, M. J, KUS, T, WYSE, D. G, LACOMBE, P, PHILIPPON, F, DUBUC, M, KERR, C. R, YEE, R, ROSE, M. S, NEWMAN, D, KAVANAGH, K. M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiac dysrhythmias
Cardiology. Vascular system
Heart
Medical sciences
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Summary:Background —Some clinical data suggest that atrial-based pacing prevents paroxysmal atrial fibrillation (AF). This study tested the hypothesis that DDDR pacing compared with VDD pacing prevents AF after atrioventricular (AV) junction ablation. Methods and Results —Patients were randomized to DDDR pacing (n=33) or to VDD pacing (n=34) after AV junction ablation and followed every 2 months for 6 months. Patients then crossed over to the alternate pacing mode and were followed for an additional 6 months. Primary analysis included the time to first recurrence of sustained AF (duration >5 minutes), total AF burden, and the development of permanent AF. The time to first episode of AF was similar in the DDDR group (0.37 days, 95% CI 0.1 to 1.3 days) and the VDD pacing group (0.5 days, 95% CI 0.2 to 1.7 days, P =NS). AF burden increased over time in both groups ( P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.102.7.736