Dopaminergic Actions of D-Amphetamine on Schedule-Induced Polydipsia in Rats

Schedule-induced polydipsia in rats was developed by means of a fixed-time 60-s schedule of food presentation. The acute administration of d-amphetamine sulfate (0.1-3.0 mg/kg) produced a dose-dependent decrease in the rate of licking. D-Amphetamine shifted to the left the temporal distribution of a...

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Bibliographic Details
Published in:The Psychological record 2007-06, Vol.57 (3), p.339-357
Main Authors: Pellon, Ricardo, Ruiz, Ana, Rodriguez, Cilia, Flores, Pilar
Format: Article
Language:English
Subjects:
Animals
Behavior
Behavior Patterns
Biochemistry
Chemical properties
Dextroamphetamine
Diagnosis
Drug Therapy
Drugs
Food
Influence
Ingestion disorders
Intervals
Motivation
Narcotics
Psychological Patterns
Rats
Rattus
Rodents
Schedules
Studies
Time
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Summary:Schedule-induced polydipsia in rats was developed by means of a fixed-time 60-s schedule of food presentation. The acute administration of d-amphetamine sulfate (0.1-3.0 mg/kg) produced a dose-dependent decrease in the rate of licking. D-Amphetamine shifted to the left the temporal distribution of adjunctive drinking within interfood intervals. Dopaminergic antagonists SCH23390 ([R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride], 0.001-0.01 mg/kg), eticlopride (0.001-0.03mg/kg), and flupenthixol (0.03-0.3 mg/kg) also produced dose-dependent decreases in licks per minute but did not alter the temporal distribution of adjunctive behavior. Selective doses of dopaminergic antagonists further suppressed licking rates when combined with d-amphetamine, 1.0 mg/kg, but an antagonism could be observed on the temporal distribution after the administration of SCH23390 (0.01 mg/kg)or flupenthixol (0.1 mg/kg). The dopaminergic agonists SKF38393 ([R(+)-1-phenyl-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-bezazepinehydrochloride]; 1.0-10.0 mg/kg) and quinpirole (0.003-0.03 mg/kg)produced a dose-dependent decrease in the rate of licking, and when combined with d-amphetamine, additive-like suppressive effects were found. These results suggest a dopaminergic selectivity for the effects of d-amphetamine on the temporal distribution of schedule-induced polydipsia. (Contains 6 figures.)
ISSN:0033-2933
2163-3452
DOI:10.1007/BF03395581