Effect of medroxyprogesterone acetate on endothelium-dependent vasodilation in postmenopausal women receiving estrogen

Estrogen increases endothelium-dependent vasodilation in postmenopausal women. However, use of progestins in combination with estrogen may counter beneficial effects of estrogen on endothelium. We investigated the effect of medroxyprogesterone acetate (MPA) on estrogen-induced increase in endotheliu...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-10, Vol.104 (15), p.1773-1778
Main Authors: WAKATSUKI, Akihiko, OKATANI, Yuji, IKENOUE, Nobuo, FUKAYA, Takao
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Flow Velocity - drug effects
Blood Pressure - drug effects
Brachial Artery - diagnostic imaging
Brachial Artery - drug effects
Brachial Artery - physiology
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, HDL - drug effects
Cholesterol, LDL - blood
Cholesterol, LDL - drug effects
Dose-Response Relationship, Drug
Drug Antagonism
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
Estradiol - blood
Estrogens, Conjugated (USP) - antagonists & inhibitors
Estrogens, Conjugated (USP) - pharmacology
Estrone - blood
Female
General and cellular metabolism. Vitamins
Heart Rate - drug effects
Humans
Japan
Lipoproteins, LDL - blood
Lipoproteins, LDL - chemistry
Medical sciences
Medroxyprogesterone Acetate - pharmacology
Middle Aged
Oxidation-Reduction
Pharmacology. Drug treatments
Postmenopause
Ultrasonography
Vascular Patency - drug effects
Vasodilation - drug effects
Vasodilation - physiology
Vasodilator Agents - pharmacology
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Summary:Estrogen increases endothelium-dependent vasodilation in postmenopausal women. However, use of progestins in combination with estrogen may counter beneficial effects of estrogen on endothelium. We investigated the effect of medroxyprogesterone acetate (MPA) on estrogen-induced increase in endothelium-dependent vasodilation in postmenopausal women. Postmenopausal women were treated daily with conjugated equine estrogen (CEE) 0.625 mg (n=14), CEE 0.625 mg and MPA 2.5 mg (n=15) or CEE 0.625 mg and MPA 5.0 mg (n=16) for 3 months. Plasma lipids and hormones were measured before and after treatment. Vasodilatory responses of the brachial artery were evaluated by measuring flow-mediated vasodilation (FMD) and nitroglycerin-induced vasodilation by use of high-resolution ultrasonography. Susceptibility of LDL to oxidation was analyzed by incubation with CuSO(4) while kinetics of conjugated diene formation was monitored. Plasma total and LDL cholesterol concentrations were decreased significantly in all groups. CEE increased FMD significantly, from 4.5+/-1.7% to 8.5+/-2.8% (P
ISSN:0009-7322
1524-4539
DOI:10.1161/hc4001.097035