The Study of PI3K/AKT Pathway in Lung Cancer Metastasis and Drug Resistance

• Published in: Zhongguo fei ai za zhi 2011-08, Vol.14 (8)
• Main Authors: ZHU, Bingjing, ZHOU, Xiangdong
• Format: Article
• Language: Chinese
• Subjects: Cell growth; Kinases; Lung cancer; Tumor necrosis factor-TNF; Vascular endothelial growth factor
• ISSN: 1009-3419; 1999-6187
• DOI: 10.3779/cjlc.v14i8.3175

磷脂酰肌醇-3-激酶/丝苏氨酸蛋白激酶（phosphatidyl-inositol 3-kinase/serine-threonine kinase, PI3K/AKT）信号通路是细胞内重要信号转导通路之一，通过影响下游多种效应分子的活化状态，在细胞内发挥抑制凋亡、促进增殖的关键作用，与人类多种肿瘤的发生发展密切相关。研究表明PI3K/AKT信号通路在恶性肿瘤细胞的增殖、血管新生和转移及对放化疗的拮抗中都起着重要作用。对PI3K/AKT信号通路的深入研究有望找到肿瘤预防和药物治疗的新靶点。本文简要介绍了PI3K/AKT信号通路的组成与功能调节，并着重阐述了其在肺癌转移和耐药中的作用。 PI3K/AKT signal pathway is an important intracellular signal transduction pathway. It plays important roles in cell apoptosis and survival by affecting the activity of downstream effector molecules, and it is closely associated with the development and progression of human tumors. Recent researches of PI3K/AKT indicate that this pathway plays important roles in tumor cells proliferation, blood vessel neogenesis, tumor metastasis and resistance to chemotherapy and radiotherapy. The profound research of PI3K/AKT is beneficial to the prevention of tumor and to the finding of potential targets for new drugs. This article reviewed the composition, function and regulation of PI3K/AKT signal pathway, and its effect in metasta