Aligned porous chitosan/graphene oxide scaffold for bone tissue engineering

[Display omitted] •3D GO/CS composite scaffolds were developed using a directional freezing technique.•The anisotropic scaffolds effectively guide MC3T3-E1 cells to be aligned.•The scaffolds improved compressive strength and simulated bone lamellar structure. Chitosan/graphene oxide composites (CGs)...

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Bibliographic Details
Published in:Materials letters 2018-12, Vol.233, p.78-81
Main Authors: Liu, Yaxin, Fang, Ning, Liu, Bin, Song, Linna, Wen, Bianying, Yang, Dongzhi
Format: Article
Language:English
Subjects:
Aligned scaffold
Alignment
Alloys
Anisotropy
Biopolymers
Bone tissue engineering
Bones
Chemical compounds
Chitosan
Composite materials
Graphene
Graphene oxide
Materials science
Protein adsorption
Proteins
Scaffolds
Shape memory
Shape memory materials
Tissue engineering
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Summary:[Display omitted] •3D GO/CS composite scaffolds were developed using a directional freezing technique.•The anisotropic scaffolds effectively guide MC3T3-E1 cells to be aligned.•The scaffolds improved compressive strength and simulated bone lamellar structure. Chitosan/graphene oxide composites (CGs) were developed using directional freezing to create aligned porous three-dimensional (3D) scaffolds resembling bone lamellae. The contact provided by the anisotropic scaffolds played a critical role in guiding the alignment of MC3T3-E1 cells along the longitudinal direction. The higher mechanical strength, shape-memory, cell alignment guiding capabilities, and protein adsorption ability, render these composites potentially useful as scaffold materials in bone tissue engineering.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2018.08.108