Adenovirus-mediated gene transfer of human platelet-activating factor--acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in

BACKGROUND: Atherosclerosis is characterized by an early inflammatory response involving proinflammatory mediators such as platelet-activating factor (PAF)-like phospholipids, which are inactivated by PAF-acetylhydrolase (PAF-AH). The effect of adenovirus-mediated expression of PAF-AH on injury-indu...

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Published in:Circulation (New York, N.Y.) N.Y.), 2001-05, Vol.103 (20), p.2495
Main Authors: Rozen Quarck, De Geest, Bart, Stengel, Dominique, Mertens, Ann
Format: Article
Language:English
Online Access:Get full text
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Summary:BACKGROUND: Atherosclerosis is characterized by an early inflammatory response involving proinflammatory mediators such as platelet-activating factor (PAF)-like phospholipids, which are inactivated by PAF-acetylhydrolase (PAF-AH). The effect of adenovirus-mediated expression of PAF-AH on injury-induced neointima formation and spontaneous atherosclerosis was studied in apolipoprotein E-deficient mice. METHODS AND RESULTS: Intravenous administration of an adenovirus (5 x 10(8) plaque-forming units) directing liver-specific expression of human PAF-AH resulted in a 3.5-fold increase of plasma PAF-AH activity at day 7 (P
ISSN:0009-7322
1524-4539