Characterization of Bio-composite Apatite/Chitosan Cement and its Antibacterial Activity

In this work, we report the physico-chemical properties and antibacterial activity of apatite/chitosan composite cements. The biocomposite was prepared by reaction between dihydrated dicalcium phosphate and calcium hydroxide in the presence of chitosan. The characterization of cement was carried out...

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Bibliographic Details
Published in:Oriental journal of chemistry 2018-01, Vol.34 (4), p.1765-1773
Main Authors: Moncif, N., Gourri, E. L. H., Elouahli, A. B. A., Ezzahmouly, M., Nayme, K., Timinouni, M., Hatim, Z.
Format: Article
Language:English
Subjects:
Antibiotics
Apatite
Bacterial infections
Biomedical materials
Calcium phosphates
Cement
Cements
Chemical properties
Chitosan
Composite materials
Grains
Image processing
Image transmission
Infections
Low resistance
Materials substitution
Organic chemistry
Polymers
Reduction
Slaked lime
Substitute bone
Surgical implants
Transmission electron microscopy
Ultrasonic testing
X ray spectra
X-ray diffraction
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Summary:In this work, we report the physico-chemical properties and antibacterial activity of apatite/chitosan composite cements. The biocomposite was prepared by reaction between dihydrated dicalcium phosphate and calcium hydroxide in the presence of chitosan. The characterization of cement was carried out by Infrared Spectroscopy, X-ray diffraction, Transmission Electron Microscopy and X-ray Scanner with computational image processing. The results show that the setting of the paste is due to the formation of a hydrated tri-calcium phosphate that evolves into a hard calcium-apatite. In the presence of chitosan, the fastness of setting time is attributed to the precipitation of chitosan that strengthens the cohesion between grains. The formed complex evolves into hard Apatite-chitosan composite. In an induced bone defect, the hard composite shows radiopaque homogenous microstructure and intimate contact bone/implant. The antibacterial tests of hard cements show a significant reduction in Staphylococci bacterial growth on the surface of composite grains. This reduction is highly dependent on the type of bacteria, and the percentage of the added antibacterial agent. Bio-composite cement shows total inhibition of Staphylococci aureus and low resistance to Staphylococci epidermidis. The apatite/chitosan composite prepared by the way of cements can have interesting applications as bone substitute material.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/340408