Sustained improvement after combined anterior mitral leaflet extension and myectomy in hypertrophic obstructive cardiomyopathy

Mitral leaflet extension (MLE) combined with septal myectomy is a new surgical approach to treat hypertrophic obstructive cardiomyopathy (HOCM) and an enlarged mitral leaflet area. The study presents the long-term clinical results and outcome of this technique. MLE entails grafting a glutaraldehyde-...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2003-10, Vol.108 (17), p.2088-2092
Main Authors: VAN DER LEE, Chris, KOFFLARD, Marcel J. M, VAN HERWERDEN, Lex A, VLETTER, Willem B, TEN CATE, Folkert J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood and lymphatic vessels
Cardiac Surgical Procedures - adverse effects
Cardiac Surgical Procedures - methods
Cardiology. Vascular system
Cardiomyopathy, Hypertrophic - surgery
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Follow-Up Studies
Glutaral - pharmacology
Heart Septum - surgery
Humans
Male
Medical sciences
Mitral Valve - surgery
Pericardium - drug effects
Pericardium - transplantation
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Transplantation, Autologous
Treatment Outcome
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Summary:Mitral leaflet extension (MLE) combined with septal myectomy is a new surgical approach to treat hypertrophic obstructive cardiomyopathy (HOCM) and an enlarged mitral leaflet area. The study presents the long-term clinical results and outcome of this technique. MLE entails grafting a glutaraldehyde-preserved autologous pericardial patch onto the center portion of the anterior mitral valve leaflet. Twenty-nine patients with HOCM were studied. Mean follow-up (+/-SD) was 3.4+/-2.1 years (range 3 months to 7.7 years). The preoperative calculated mitral leaflet area was 16.7+/-3.4 cm2. New York Heart Association functional class improved significantly from 2.8+/-0.4 to 1.3+/-0.4 (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000092912.57140.14