RRM1 expression in tissue microarray and prognosis analysis in non-small cell lung cancer

RRM1与非小细胞肺癌的预后可能有关。本研究的目的是采用组织芯片技术检测非小细胞肺癌中RRM1的表达并分析预后因素。方法 取广东省肺癌研究所标本库的417例非小细胞肺癌术后标本制作成组织芯片。通过SP法检测RRM1的表达情况并分析其与预后的关系。结果 RRM1在不同的性别、年龄、肿瘤部位、病理类型、分化程度、T状态、N状态、M状态和病理分期等组间的差异均无统计学意义（P均 > 0.05）。单因素分析显示RRM1表达不是有统计学意义的预后因素（P > 0.05）。COX模型多因素分析显示,分化程度、N状态是独立的预后因素。结论 通过免疫组化检测的RRM1表达不能作为非小细胞肺癌独立的...

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Published in:Zhongguo fei ai za zhi 2006-10, Vol.9 (5)
Main Authors: LIAO, Riqiang, LIN, Jiayin, QIAO, Guibin, LUO, Xinlan, YANG, Jingji, HUANG, Yujuan, WU, Yilong
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Lung cancer
Medical prognosis
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container_title Zhongguo fei ai za zhi
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LIN, Jiayin
QIAO, Guibin
LUO, Xinlan
YANG, Jingji
HUANG, Yujuan
WU, Yilong
description RRM1与非小细胞肺癌的预后可能有关。本研究的目的是采用组织芯片技术检测非小细胞肺癌中RRM1的表达并分析预后因素。方法 取广东省肺癌研究所标本库的417例非小细胞肺癌术后标本制作成组织芯片。通过SP法检测RRM1的表达情况并分析其与预后的关系。结果 RRM1在不同的性别、年龄、肿瘤部位、病理类型、分化程度、T状态、N状态、M状态和病理分期等组间的差异均无统计学意义（P均 > 0.05）。单因素分析显示RRM1表达不是有统计学意义的预后因素（P > 0.05）。COX模型多因素分析显示,分化程度、N状态是独立的预后因素。结论 通过免疫组化检测的RRM1表达不能作为非小细胞肺癌独立的预后因素。TNM分期仍然是目前最好的预后因素。 Background and objective RRM1 may be a prognostic factor in non-small cell lung cancer （NSCLC）. The aim of this study is to evaluate RRM1 expression and prognosis in NSCLC by the means of tissue microarray. Methods A total of 417 paraffin-embedded specimens of NSCLC from Lung Cancer Study Center in Guangdong Provincial People’s Hospital were collected and tissue microarray was constructed. RRM1 expression was detected by SP method and its correlation with prognosis was evaluated. Results No statistic difference was found in RRM1 expression in different gender, age, tumor site, histology, differentiation, T stage, N stage, M stage and pTNM stage groups （P > 0.05）. Univariate analysis showed that RR
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The aim of this study is to evaluate RRM1 expression and prognosis in NSCLC by the means of tissue microarray. Methods A total of 417 paraffin-embedded specimens of NSCLC from Lung Cancer Study Center in Guangdong Provincial People’s Hospital were collected and tissue microarray was constructed. RRM1 expression was detected by SP method and its correlation with prognosis was evaluated. Results No statistic difference was found in RRM1 expression in different gender, age, tumor site, histology, differentiation, T stage, N stage, M stage and pTNM stage groups （P &gt; 0.05）. 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title RRM1 expression in tissue microarray and prognosis analysis in non-small cell lung cancer
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