Synthesis of New Tetrazole Derivatives and Their Biological Evaluation

An operationally simple and efficient method of synthesis of novel 1,5-disubstituted tetrazoles with high yields from easily accessible 2-(2-benzamido-3-arylacrylamido)acetate under mild conditions is developed. Anticancer and anti-microbial tests of the new tetrazole derivatives have been carried o...

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Bibliographic Details
Published in:Russian journal of general chemistry 2018-08, Vol.88 (8), p.1726-1733
Main Authors: Soliman, H. A., Kalmouch, A., Awad, H. M., Abdel Wahed, N. A. M.
Format: Article
Language:English
Subjects:
Acetates
Anti-infective agents
Antiinfectives and antibacterials
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
Microorganisms
Peptides
Synthesis
Tetrazoles
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Summary:An operationally simple and efficient method of synthesis of novel 1,5-disubstituted tetrazoles with high yields from easily accessible 2-(2-benzamido-3-arylacrylamido)acetate under mild conditions is developed. Anticancer and anti-microbial tests of the new tetrazole derivatives have been carried out.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363218080273