Evaluation of chronic kidney disease in cancer patients: is there a preferred estimation formula?

Background The evaluation of chronic kidney disease (CKD) in cancer patients seems to rely mostly on the Cockcroft‐Gault (CG) formula or the creatinine levels to adjust treatment dosages which is a practice refuted by internists. Aims We evaluate the overall agreement of the CG, modification of diet...

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Bibliographic Details
Published in:Internal medicine journal 2018-11, Vol.48 (11), p.1382-1388
Main Authors: Sleilalty, Ghassan, El Rassy, Elie, Assi, Tarek, Al Rassy, Nathalie, Naseh, Jessica, Rizkallah, Jamale, Finianos, Serge, Azar, Hiba, Chelala, Dania N., El Karak, Fadi, Kattan, Joseph, Ghosn, Marwan
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - diagnosis
Adult
Aged
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Area Under Curve
Cancer
CKD‐EPI
Cockcroft‐Gault
Creatinine
Creatinine - blood
Epidermal growth factor receptors
Female
Glomerular Filtration Rate
Humans
Janowitz equation
Kidney diseases
kidney function
Kidney Function Tests - standards
Kidneys
Male
MDRD
Middle Aged
Neoplasms - complications
Neoplasms - drug therapy
onconephrology
Patients
Predictive Value of Tests
Renal function
Renal Insufficiency, Chronic - chemically induced
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - diet therapy
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Summary:Background The evaluation of chronic kidney disease (CKD) in cancer patients seems to rely mostly on the Cockcroft‐Gault (CG) formula or the creatinine levels to adjust treatment dosages which is a practice refuted by internists. Aims We evaluate the overall agreement of the CG, modification of diet in renal disease (MDRD) and CKD–epidemiology collaboration equations (CKD‐EPI) equation with the newly devised Janowitz and Williams’ (JW) equation. Methods The renal function was estimated in 235 cancer patients according to the CG, MDRD, body surface area (BSA)‐adjusted MDRD, CKD‐EPI, BSA‐adjusted CKD‐EPI and JW formulae. Results JW equation was more in agreement with CG and CKD‐EPI estimations than the other equations. Taking JW equation as reference, receiver operating characteristic curve analysis showed that CG eGFR had the higher area under the curve when compared with other equations. Hierarchical cluster analysis showed more proximity between CG and JW equations than the other equations. Conclusion The newly proposed JW eGFR estimation was more in agreement with CG equation than the other equations.
ISSN:1444-0903
1445-5994
DOI:10.1111/imj.13933