Bax and TGFβRII frameshift mutations in lung cancer

To explore frameshift mutations in the Bax and TGFβRII genes and the relationship between frameshift mutations and microsatellite alterations in lung cancer. Frameshift mutations and microsatellite alterations were detected in 50 primary lung cancer tissues by PCR,8% denature polyacrylamide gel elec...

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Bibliographic Details
Published in:Zhongguo fei ai za zhi 2000-10, Vol.3 (5), p.348
Main Authors: Chen, G, Liu, T, Zhang, W, Li, S, Yang, D, Sun, Y
Format: Article
Language:Chinese
Subjects:
Lung cancer
Mutation
Online Access:Get full text
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Summary:To explore frameshift mutations in the Bax and TGFβRII genes and the relationship between frameshift mutations and microsatellite alterations in lung cancer. Frameshift mutations and microsatellite alterations were detected in 50 primary lung cancer tissues by PCR,8% denature polyacrylamide gel electrophoresis and silver staining. Bax gene (G)₈ frameshift mutations were detected in 12 cases (24%，12/50),and all were base deletion mutations.Bax frameshift mutations correlated with microsatellite alterations (P
ISSN:1009-3419
1999-6187
DOI:10.3779/cjlc.v3i5.1645