Expression of P-gp, MRP and p53 and their clinical significance in human lung cancer tissues

To investigate the clinical roles of P-gp, MRP and p53 expression and their relationship with one another in primary lung cancer. P-gp, MRP and p53 proteins were measured in 31 paraffin-embedded lung cancer tissues and corresponding normal lung tissues by immunohistochemistry(IHC). In addition, flow...

Full description

Saved in:
Bibliographic Details
Published in:Zhongguo fei ai za zhi 2001-02, Vol.4 (1), p.58
Main Authors: Rui, M, Li, L, Liu, L, Wang, J, Zhang, Z
Format: Article
Language:Chinese
Subjects:
Clinical significance
Lung cancer
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the clinical roles of P-gp, MRP and p53 expression and their relationship with one another in primary lung cancer. P-gp, MRP and p53 proteins were measured in 31 paraffin-embedded lung cancer tissues and corresponding normal lung tissues by immunohistochemistry(IHC). In addition, flow cytometric analysis of P-gp and p53 was performed in 29 of 31 frozen lung cancer specimens in order to compare the results of the two methods. By IHC, positive rates of P-gp, MRP and p53 were 61.3%, 54.8%, 71.0% respectively in 31 lung cancer cases and there was no expression in all normal lung tissues. P-gp and MRP expressed only in NSCLC. The poorer the cancer cell differentiated, the lower the positive rate of P-gp expression was (P
ISSN:1009-3419
1999-6187
DOI:10.3779/cjlc.v4i1.1724