Effects of IL-4 and taxol on cellular proliferation of Lewis lung cancer

• Published in: Zhongguo fei ai za zhi 2000-08, Vol.3 (4), p.257
• Main Authors: Hu, X, Liu, M, Yu, L, Chen, D, Jiang, M, Liu, X, Xia, D, Zhang, Z
• Format: Article
• Language: Chinese
• Subjects: Lung cancer; Rodents
• ISSN: 1009-3419; 1999-6187
• DOI: 10.3779/cjlc.v3i4.1598

To investigate the effects of IL-4 and taxol on cellular proliferation of Lewis lung cancer (LLC) . LLC cells (1. 25 *10(6)/ mouse) were inoculated subcutaneously to 40 mice , which were randomized into 4 groups and given responsive treatment consecutively in 5 days after inoculation. For group I natrii chloride was injected , for group II IL-4 at 50 ng/ d for 7 days , for group III taxol at 10 mg/ (kg*d) for 10 days , and for group IV IL-4 and taxol were injected altogether at 50 ng/ d for 7 days and 5mg/ (kg*d) for 10 days respectively. On the 18th day , all the mice were killed. Nuclear morphometry , DNA contents and AgNORs were detected by image analysis. Nuclear area , perimeter , mean diameter , DNA contents , and AgNORs counting in group II were 24. 202 +/-5. 012mum(2) , 18. 626 +/-4. 180mum , 2. 642 +/-0. 291mum , 3. 412 +/-0. 910 , and 5. 313 +/-0. 820 respectively , which were significantly less than those in group I ( P < 0. 05) ; the parameters in group III were 18. 373 +/-4. 833mum(2) , 16. 522 +