Chitosan/Polyvinylpyrrolidone/MCM‐41 Composite Hydrogel Films: Structural, Thermal, Surface, and Antibacterial Properties

• Published in: Starch 2018-11, Vol.70 (11-12), p.n/a
• Main Authors: Ulu, Ahmet, Noma, Samir A. A., Gurses, Canbolat, Koytepe, Suleyman, Ates, Burhan
• Format: Article
• Language: English
• Subjects: antibacterial; Chitosan; composite hydrogels; Degradability; Drug delivery; Drug delivery systems; E coli; Hydrogels; Materials selection; MCM‐41; Miscibility; Moisture content; Permeability; Physical characteristics; Polyvinylpyrrolidone; Properties (attributes); PVP; Scanning electron microscopy; Swelling; Thermal stability; Water content; Wettability; Wound healing; Yeast
• ISSN: 0038-9056; 1521-379X
• DOI: 10.1002/star.201700303

The aim of this study is to characterize and investigate the effects of the Mobil Composition of Matter No. 41 (MCM‐41) concentrations (0.5, 1, 3, 5, and 10 wt%) on structural, thermal, wettability, water content, oxygen (O2) permeability, and swelling properties as well as morphological characteristics of chitosan/polyvinylpyrrolidone/MCM‐41 (CH/PVP/MCM‐41) composite hydrogel films. In addition, hydrolytic degradability, optic transmittance, and antibacterial properties of composite hydrogels films are determined as in vitro. With increasing of MCM‐41 content, the composite hydrogels showed higher thermal stability, as expected. The morphologic properties of the composite hydrogel films are studied using scanning electron microscope (SEM) technique that provide evidence for good miscibility of CH, PVP, and MCM‐41. The swelling and water‐absorbing properties of the composite hydrogel films are significantly improved because of enhanced hydrophilic profile. Furthermore, the antimicrobial properties of the prepared composite hydrogel films are studied against Bacillus subtilis, Escherichia coli, and Candida albicans yeast. The results showed excellent antibacterial behavior of the composite hydrogel films. The study clearly demonstrates that the prepared CH/PVP/MCM‐41 composite hydrogel films may be used as a promising candidate material in various fields such as drug delivery, wound healing material, and adsorbent materials. Chitosan/polyvinylpyrrolidone/MCM‐41 (CH/PVP/MCM‐41) composite hydrogels with different MCM‐41 contents (0.5, 1, 3, 5 and 10 wt%) exhibit significantly different thermal stability, water uptake and swelling ratio properties in compared with CH/PVP hydrogels. These composite hydrogels have also excellent antimicrobial activity against E. coli (G−), B. subtilis (G+) and C. albicans and show potential for biomedical applications.