Ruthenium (II)‐Catalyzed Oxidant‐Free Coupling/Cyclization of Benzimidates and Sulfoxonium Ylides to Form Substituted Isoquinolines

A ruthenium‐catalyzed direct mono‐C−H functionalization/annulation cascade reaction of benzimidates and sulfoxonium ylides has been developed. The reaction proceeds smoothly with a broad range of substrates, giving access to a variety of isoquinoline derivatives in moderate to good yields using an o...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2018-11, Vol.360 (21), p.4049-4053
Main Authors: Shi, Xinxia, Wang, Rongchao, Zeng, Xiaofei, Zhang, Yilan, Hu, Huiling, Xie, Chunsong, Wang, Min
Format: Article
Language:English
Subjects:
Benzimidate
Cascade chemical reactions
Chemical reactions
Isoquinoline
Organic chemistry
Oxidant-free
Ruthenium
Ruthenium catalyst
Substrates
Sulfoxonium ylide
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Summary:A ruthenium‐catalyzed direct mono‐C−H functionalization/annulation cascade reaction of benzimidates and sulfoxonium ylides has been developed. The reaction proceeds smoothly with a broad range of substrates, giving access to a variety of isoquinoline derivatives in moderate to good yields using an organic acid additive under oxidant free conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201800844