Two New Flavones from the Barks of Cassia alata and their Bioactivity

Two new flavones ( 1 and 2 ), together with two known flavones ( 3 and 4 ), were isolated from the barks of Cassia alata. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 – 4 were evaluated for their anti-methicillin-resistant Stap...

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Published in:Chemistry of natural compounds 2018-11, Vol.54 (6), p.1052-1056
Main Authors: Liu, Xin, Kong, Wei-Song, Li, Ping, Li, Jing, Ye, Lin, Gen, Yong-Qin, Jiang, Ci-Qing, Li, Yan-Ping, Rao, Gao-Xiong, Zhou, Min, Guangyu-Yang, Li, Xue-Mei, Hu, Qiu-Fen
Format: Article
Language:English
Subjects:
Antioxidants
Medicine
NMR
Nuclear magnetic resonance
Organic Chemistry
Pharmacy
Plant Sciences
Staphylococcus infections
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Summary:Two new flavones ( 1 and 2 ), together with two known flavones ( 3 and 4 ), were isolated from the barks of Cassia alata. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 – 4 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compound 1 showed good inhibition with IZD of 13.8 ± 1.0 mm. Compounds 2 – 4 also showed weak inhibition with IZD of 11.2 ± 0.8, 9.6 ± 0.6, and 7.8 ± 0.7 mm, respectively. Compounds 1 and 2 were also tested for their antioxidant activity, and show good antioxidant activity with an IC 50 values of 4.8 and 4.5 μg/mL, respectively.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-018-2553-2