Modification of tetrahydrocarbazoles with pharmacophore ligands by copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition

A synthetic approach to the modification of tetrahydrocarbazoles with pharmacophore ligands (carbazole, tetrahydrocarbazole, and phenothiazine) was proposed based on the coppercatalyzed alkyne-azide 1,3-dipolar cycloaddition of azide-containing tetrahydrocarbazoles and propargyl-containing carbazole...

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Bibliographic Details
Published in:Russian chemical bulletin 2018-09, Vol.67 (9), p.1679-1683
Main Authors: Sokolov, V. B., Aksinenko, A. Yu, Epishina, T. A., Goreva, T. V.
Format: Article
Language:English
Subjects:
Alkynes
Carbazoles
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cycloaddition
Inorganic Chemistry
Ligands
Organic Chemistry
Pharmacology
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Summary:A synthetic approach to the modification of tetrahydrocarbazoles with pharmacophore ligands (carbazole, tetrahydrocarbazole, and phenothiazine) was proposed based on the coppercatalyzed alkyne-azide 1,3-dipolar cycloaddition of azide-containing tetrahydrocarbazoles and propargyl-containing carbazole, tetrahydrocarbazole, and phenothiazine.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-018-2276-3