Treatment with nitric oxide in the neonatal intensive care unit is associated with increased risk of childhood cancer

Aim This study aimed to determine whether neonatal intensive care therapies increase the risk of carcinogenesis in childhood. Methods This study used population‐based data on 1 072 957 infants born in New South Wales, Australia, between 2000 and 2011 and multivariate logistic regression to examine a...

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Bibliographic Details
Published in:Acta Paediatrica 2018-12, Vol.107 (12), p.2092-2098
Main Authors: Dixon, Fiona, Ziegler, David S, Bajuk, Barbara, Wright, Ian, Hilder, Lisa, Abdel Latif, Mohamed E., Somanathan, Aranie, Oei, Ju Lee
Format: Article
Language:English
Subjects:
Birth weight
Cancer
Carcinogenesis
Childhood
Childhood cancer
Children
Gestation
Health risk assessment
Health risks
Infants
Intensive care
Linkage
Neonatal intensive care unit
Neonates
Nitric oxide
Population studies
Premature birth
Preterm
Tumors
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Summary:Aim This study aimed to determine whether neonatal intensive care therapies increase the risk of carcinogenesis in childhood. Methods This study used population‐based data on 1 072 957 infants born in New South Wales, Australia, between 2000 and 2011 and multivariate logistic regression to examine any associations between therapies used in the neonatal intensive care unit and diagnoses of cancer until mid 2012. Results A total of 1126 of 1 072 957 (0.1%) children were diagnosed with cancer. Cancer risk was significantly increased by preterm birth (gestation
ISSN:0803-5253
1651-2227
DOI:10.1111/apa.14436