Spatial Structure and Conformational Mobility of Seven-Membered Cyclic Acetals and Ketals Containing Pyridoxine Moiety in Solution by NMR Methods

In the last decade, pyridoxine derivatives were widely used for the synthesis of molecules with important biological and physical properties. However, rational synthesis of the compounds with desirable biochemical or physical properties often requires information about their spatial structure and co...

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Bibliographic Details
Published in:BioNanoScience 2018-12, Vol.8 (4), p.963-970
Main Authors: Rakhmatullin, I. Z., Galiullina, L. F., Balandina, A. A., Karataeva, F. K., Shtyrlin, Y. G., Klochkov, V. V.
Format: Article
Language:English
Subjects:
Acetals
Acetone
Biological and Medical Physics
Biological properties
Biomaterials
Biophysics
Chemical synthesis
Circuits and Systems
Conformational analysis
Derivatives
Engineering
Exchanging
Magnetic resonance spectroscopy
Mobility
Nanotechnology
NMR spectroscopy
Physical properties
Pyridoxine
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Summary:In the last decade, pyridoxine derivatives were widely used for the synthesis of molecules with important biological and physical properties. However, rational synthesis of the compounds with desirable biochemical or physical properties often requires information about their spatial structure and conformational mobility. NMR spectroscopy is a powerful tool for conformational analysis of biologically important samples, such as pyridoxine derivatives, in solution. This paper is devoted to a review of the results obtained by our group over the last 5 years on the NMR study of nine newly synthesized pyridoxine derivatives in acetone solution. It was shown that studied compounds are involved into several conformational exchange processes. The activation energies of all observed conformational exchange processes were calculated.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-018-0562-z