Pogostemins A-C, three new cytotoxic meroterpenoids from Pogostemon auricularius

Pogostemins A-C (1–3), three new meroterpenoids with pyrone-sesquiterpenoid hybrid skeletons, were isolated from the aerial parts of Pogostemon auricularius. Their chemical structures were elucidated by 1D- and 2D-NMR and HRESIMS analyses. Compound 1 showed significant cytotoxicities against the hum...

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Bibliographic Details
Published in:Fitoterapia 2018-10, Vol.130, p.100-104
Main Authors: Nguyen, Hoai Thi, Tran, Linh Thuy Thi, Ho, Duc Viet, Le, Dung Viet, Raal, Ain, Morita, Hiroyuki
Format: Article
Language:English
Subjects:
Adenocarcinoma
Cancer
Chemical compounds
Colon
Colorectal cancer
Cytotoxicity
Gastric cancer
Hepatoma
Herbal medicine
Lamiaceae
Lung cancer
NMR
Nuclear magnetic resonance
Organic chemistry
pogostemins A-C
Pogostemon
Pogostemon auricularius
Tumor cell lines
Two dimensional analysis
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Summary:Pogostemins A-C (1–3), three new meroterpenoids with pyrone-sesquiterpenoid hybrid skeletons, were isolated from the aerial parts of Pogostemon auricularius. Their chemical structures were elucidated by 1D- and 2D-NMR and HRESIMS analyses. Compound 1 showed significant cytotoxicities against the human colon adenocarcinoma SW-480, epidermoid carcinoma KB, gastric cancer AGS, hepatoma cancer Hep-G2, and lung cancer LU-1 cell lines with IC50 values of 7.21, 8.49, 9.44, 11.75, and 12.76 μg/mL, respectively. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2018.08.015