Cognitive dysfunction in multiple sclerosis: The effect of pharmacological interventions

Research has recently focused on cognitive dysfunction in multiple sclerosis (MS). Cognitive deficits are frequently encountered in patients and account for important impairment in quality of life, therefore posing a major therapeutic challenge for the disease. We presently review studies on cogniti...

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Bibliographic Details
Published in:International review of psychiatry (Abingdon, England) England), 2010, Vol.22 (1), p.35-42
Main Authors: Lyros, Epameinondas, Messinis, Lambros, Papageorgiou, Sokratis G., Papathanasopoulos, Panagiotis
Format: Article
Language:English
Subjects:
Cholinesterase Inhibitors - therapeutic use
Clinical Trials as Topic
Cognition
Cognition Disorders - complications
Cognition Disorders - drug therapy
Cognition Disorders - epidemiology
Cognitive ability
Drug therapy
Humans
Immunomodulation
Interferons - therapeutic use
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - drug therapy
Multiple Sclerosis - epidemiology
Multiple Sclerosis - psychology
Patients
Psychopharmacology
Quality of life
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Summary:Research has recently focused on cognitive dysfunction in multiple sclerosis (MS). Cognitive deficits are frequently encountered in patients and account for important impairment in quality of life, therefore posing a major therapeutic challenge for the disease. We presently review studies on cognitive effects of pharmacological treatments in MS. There is evidence for a possible beneficial effect of immunomodulatory treatments, particularly of interferons, and also of acetylcholinesterase inhibitors on cognition in MS, which, however, requires evaluation in larger, multi-centre, longitudinal studies. Methodological issues and future prospects regarding the investigation of this issue are also discussed.
ISSN:0954-0261
1369-1627
DOI:10.3109/09540261003589455