Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-N-[4-chloro-3-(Trifluoromethyl)Phenyl]-4-Morpholino-1H-Indazole-1-Carboxamide

Compound 3-amino-N-[4-chloro-3-(trifluoromethyl)phenyl]-4-morpholino-1H-indazole-1-carboxamide has been synthesised by condensation of 1-chloro-4-isocyanato-2-(trifluoromethyl)benzene with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine...

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Bibliographic Details
Published in:Journal of chemical research 2018-10, Vol.42 (10), p.504-507
Main Authors: Ji, Xiao-hui, Jin, Ling-xia, Zhao, Cai-bin, Zheng, Nan, Song, Juan, Ge, Hong-guang, Liu, Quan, Lu, Jiu-fu
Format: Article
Language:English
Subjects:
Anticancer properties
Benzene
Crystal structure
Hydrazines
Morpholine
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Summary:Compound 3-amino-N-[4-chloro-3-(trifluoromethyl)phenyl]-4-morpholino-1H-indazole-1-carboxamide has been synthesised by condensation of 1-chloro-4-isocyanato-2-(trifluoromethyl)benzene with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the compound possesses a distinct inhibitory capacity against proliferation of the A549 and BGC-823 cancer cell lines.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751918X15380423621264