Glutathione-S-transferase polymorphism and clinical features of acute drug poisoning in children

We studied the association of GSTM1 and GSTT1 and GSTP1 Ile105-Val105 polymorphism with the duration of intoxication, polyorgan failure, and severity of drug poisoning in children. The combination of GSTM1 and GSTT1 zero genotypes is a favorable sign for the duration of intoxication and severity of...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-04, Vol.139 (4), p.431-433
Main Authors: Vavilin, V A, Safronova, O G, Manankin, N A, Kaznacheeva, L F, Lyakhovich, V V
Format: Article
Language:English
Subjects:
Child
Confidence Intervals
Glutathione Transferase - genetics
Humans
Odds Ratio
Poisoning - enzymology
Poisoning - genetics
Polymorphism, Genetic
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Summary:We studied the association of GSTM1 and GSTT1 and GSTP1 Ile105-Val105 polymorphism with the duration of intoxication, polyorgan failure, and severity of drug poisoning in children. The combination of GSTM1 and GSTT1 zero genotypes is a favorable sign for the duration of intoxication and severity of the disease.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0314-2