Negative inotropic and chronotropic effects of [delta]-opioid receptor antagonists are mediated via non-opioid receptors

• Published in: Bulletin of experimental biology and medicine 2006-04, Vol.141 (4), p.420
• Main Authors: Maslov, L N, Lishmanov, Yu B, Barzakh, E I, Lasukova, T V, Rice, K K, Oeltgen, P R
• Format: Article
• Language: English
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-006-0188-y

Issue Title: This issue is a translation of Byulleten' Eksperimental'noi Biologii i Meditsiny (Bulletin of Experimental Biology and Medicine) and Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Ten-minute perfusion of intact isolated rat heart with Krebs-Henseleit solution containing δ-opioid receptor agonists (DPDPE, (-)-TAN-67) or δ-opioid receptor antagonists (naltrindole, TIPP[Ψ], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the rates of myocardial contraction and relaxation. Intravenous injection of δ-agonists (DPDPE, (-)-TAN-67, deltorphin II) or δ-antagonists (naltrindole, TIPP[Ψ], ICI 174,864) decreased HR in narcotized rats. Naloxone and naltrexone produced no effect on contractility and HR both in vivo and in vitro. Preliminary injection of naloxone and naltrexone did not prevent the negative chronotropic effect of ICI 174,864 in vitro. The negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated by unknown non-opioid receptors in the heart.