Role of the Serotoninergic System in the Development of Diseases of the Intestinal and Biliferous Tracts

Primary sclerosing cholangitis and nonspecific ulcerative colitis were modeled before and after serotonin and spiperone injections. Activation of the serotoninergic system prevented the development of primary sclerosing cholangitis, but promoted more severe course of nonspecific ulcerative colitis.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-05, Vol.147 (5), p.655-660
Main Author: Lychkova, A. E
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
cholangitis
Cholangitis, Sclerosing - chemically induced
Cholangitis, Sclerosing - physiopathology
Colitis, Ulcerative - chemically induced
Colitis, Ulcerative - physiopathology
Dopamine Antagonists - pharmacology
electromotor activity
GABA Modulators - pharmacology
Internal Medicine
Laboratory Medicine
Morphology and Pathomorphology
Myocytes, Smooth Muscle - drug effects
Pathology
Pentobarbital - pharmacology
Pentobarbital - therapeutic use
Rats
Rats, Wistar
serotonin
Serotonin - metabolism
Serotonin - pharmacology
Serotonin 5-HT2 Receptor Antagonists
Serotonin Agents - pharmacology
spiperone
Spiperone - metabolism
Spiperone - pharmacology
Trinitrobenzenesulfonic Acid - toxicity
ulcerative colitis
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Description
Summary:Primary sclerosing cholangitis and nonspecific ulcerative colitis were modeled before and after serotonin and spiperone injections. Activation of the serotoninergic system prevented the development of primary sclerosing cholangitis, but promoted more severe course of nonspecific ulcerative colitis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0588-x