N-Propargyl-α-aminophosphonates in 1,3-Dipolar Cycloaddition with Azide-Containing Pharmacophores

Some transformations of N -propargyl-α-aminophosphonates synthesized by the Kubachnik–Fields reaction were studied in copper-catalyzed 1,3-dipolar cycloaddition with azide-containing pharmacophores (phenothiazine, tetrahydrocarbazole, carbazole, and 3,5-dimethyl-1-aminoadamantane) leading to the for...

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Bibliographic Details
Published in:Russian journal of general chemistry 2018-09, Vol.88 (9), p.1922-1926
Main Authors: Sokolov, V. B., Aksinenko, A. Yu
Format: Article
Language:English
Subjects:
Carbazoles
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cycloaddition
Letters to the Editor
Pharmacology
Triazoles
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Summary:Some transformations of N -propargyl-α-aminophosphonates synthesized by the Kubachnik–Fields reaction were studied in copper-catalyzed 1,3-dipolar cycloaddition with azide-containing pharmacophores (phenothiazine, tetrahydrocarbazole, carbazole, and 3,5-dimethyl-1-aminoadamantane) leading to the formation of the corresponding 1,4-substituted 1,2,3-triazoles and allowing the introduction of a diethoxyphosphoryl fragment into the molecules of potential neuroprotectors.
ISSN:1070-3632
1608-3350
DOI:10.1134/S107036321809027X