Comparative study of vasaprostan and alprostan in spontaneous platelet aggregation test in mice

We propose a method for evaluation of spontaneous aggregation of mouse platelets based on routine clinical blood tests for humans. Comparative analysis of Vasaprostan and Alprostan drugs showed that this test can be used for testing of new drugs on animals.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-10, Vol.138 (4), p.423
Main Authors: Gol'dshtein, D V, Maevskii, E I, Pogorelova, V N
Format: Article
Language:English
Online Access:Get full text
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Description
Summary:We propose a method for evaluation of spontaneous aggregation of mouse platelets based on routine clinical blood tests for humans. Comparative analysis of Vasaprostan and Alprostan drugs showed that this test can be used for testing of new drugs on animals.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0059-y