Ceruloplasmin prevents hemostatic disorders during experimental hyperammonemia

Experimental hyperammonemia in rats was accompanied by hemostatic disorders manifesting in coagulopathy (activation of the intrinsic pathway of blood coagulation) and suppression of platelet function. Ceruloplasmin in a total dose of 60 mg/kg effectively normalized coagulation hemostasis and functio...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-10, Vol.142 (4), p.416-418
Main Authors: Osikov, M V, Makarov, E V, Krivokhizhina, L V
Format: Article
Language:English
Subjects:
Animals
Blood Coagulation - drug effects
Blood Platelets - drug effects
Blood Platelets - physiology
Calcification, Physiologic - drug effects
Ceruloplasmin - therapeutic use
Fibrinogen - metabolism
Hemostatic Disorders - chemically induced
Hemostatic Disorders - prevention & control
Hyperammonemia - complications
Male
Platelet Aggregation - drug effects
Rats
Thrombin Time
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Summary:Experimental hyperammonemia in rats was accompanied by hemostatic disorders manifesting in coagulopathy (activation of the intrinsic pathway of blood coagulation) and suppression of platelet function. Ceruloplasmin in a total dose of 60 mg/kg effectively normalized coagulation hemostasis and functional activity of platelets by improving secretory processes in platelets and increasing aggregation rate.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0380-0